HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2
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چکیده
منابع مشابه
HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2
To explore the relationship between innate immunity and hepatitis C Virus (HCV) in determining the risk of cirrhosis (CIR), hepatocellular carcinoma (HCC), mixed cryoglobulinemia syndrome (MCS) and non-Hodgkin lymphoma (NHL), we investigated the impact of the toll-like receptor-2 (TLR2) and interleukin-28B (IL28B) genetic variants. TLR2 -174 del variant was associated with TLR2 expression and w...
متن کاملNotch4 and mhc class II polymorphisms are associated with hcv-related benign and malignant lymphoproliferative diseases
Mixed cryoglobulinemia (MC), is a HCV-related, clinically benign, lymphoproliferative disorder (LPD) that may evolve into a non Hodgkin's lymphoma (NHL). Significant associations were found between two single nucleotide polymorphisms near NOTCH4 (rs2071286) and the HLA class II (rs9461776) genes and HCV-related MC syndrome (MCS). We analyzed NOTCH4 rs2071286 and HLA-II rs9461776 in 3 HCV-relate...
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abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...
15 صفحه اولNo impact of IL28B polymorphisms on liver enzymes in patients coinfected with HIV and HCV
Results A total of 124 patients (44% normal ALT levels, median age 42 years, 68% males, 93% IDUs, 33% alcohol abuse, 5% HBsAg+, median CD4 count 511 cells/μL, median serum HCV-RNA 6.05 log10 copies/mL, 62% HCV genotype 1) were analyzed. Overall 34% of the whole population displayed the IL-28B CC genotype. When comparing ALT groups, 18 (32.7%) with normal ALT showed CC vs 25 (36.2%) with elevate...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.9303